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| posted on 4/25/2017 at 11:19 AM|
Scientists in Texas closer to diabetes cure with unconventional treatment
by Marty Toohey, American-Statesman Staff, NCD
14 hours ago
Years of testing remain, but UT Health San Antonio researchers say they’ve cured Type 1 diabetes in mice.
In peer-reviewed paper, they say a "gene transfer" can "wake up" cells in the pancreas to produce insulin.
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Health researchers at the University of Texas think they have found a way to trick the body into curing Type 1 diabetes.
The immune system of a person with diabetes kills off useful "beta" cells, but the UT researchers say they have found a way to make other cells in the pancreas perform the necessary work. Their approach, announced earlier this month in the academic journal Current Pharmaceutical Biotechnology, not only would have implications for Type 1, formerly called juvenile diabetes, but also could help treat the far more common Type 2 variety, also known as adult-onset diabetes.
The researchers have cured mice, which are genetically similar to people but different enough that new rounds of animal testing — and millions of dollars more — are needed before human trials can begin. The researchers’ approach is sure to garner skeptics, at least in part because it is a significant departure from the many other attempts at curing diabetes, which typically involve transplanting new cells and/or suppressing the immune system’s attempts to kill off useful ones.
By contrast, "we’re taking a cell that is already present in the body — it’s there, and it’s happy — and programming it to secrete insulin, without changing it otherwise," said Ralph DeFronzo, chief of the diabetes research at the UT Health Science Center at San Antonio.
Diabetes is a disease characterized by a person’s inability to process carbohydrates, a condition that if untreated can lead to often-catastrophic health consequences: lethargy, diminished eyesight, heart attacks, strokes, blindness and a loss of circulation in the feet that could lead to amputation. The Centers for Disease Control and Prevention estimate that in 2014, about 29 million Americans – almost 1 in 10 – had diabetes.
The core problem is insulin. Most people naturally secrete that substance when they eat something with carbohydrates, such as bread, potatoes and candy bars. Insulin acts like a concierge that escorts the sugar from the bloodstream into the cells, providing the cells with the energy to function. In most people, the body is continually monitoring blood sugar and producing insulin as needed.
In Type 2 diabetes — which makes up 9 out of 10 diabetes cases and is generally associated with older people and weight gain — the cells reject the insulin, causing sugar to build up in the bloodstream even as cells are starved for energy. Type 2 is often treated with pills that tell the cells to let in the insulin. But in Type 2 diabetes, the body also often gradually loses the ability to produce insulin, requiring insulin injections.
In Type 1 — the type the researchers studied — the body has simply stopped producing insulin. This type often manifests in children, though it can sometimes develop in adults as well.
The reason the body stops producing insulin is that it kills off the pancreas’ beta cells, which produce insulin. People with Type 1 diabetes must get their insulin from injections or ingestion, a cumbersome and often imprecise task. Too little insulin and blood sugar levels stay high for extended periods, potentially damaging the body; too much and blood sugar levels crash, possibly causing a person with diabetes to faint or experience an even worse problems, such as a stroke.
DeFronzo’s partner, Bruno Doiron, decided to see whether the body could reliably produce insulin without transplanting new cells. He used a "gene transfer" technique on mice, delivered via a virus, that activated insulin production in cells already in the pancreas — for instance, those that produced certain enzymes.
"We’re not fundamentally changing the cell," DeFronzo said. "We’re just giving it one additional task."
The mice immune systems did not attack the new insulin-producing cells. Most important, according to the findings: The cells produced the right amount of insulin: not so much that they sent a mouse into a blood sugar free fall, not so little that blood sugar levels stayed high. The mice have shown no sign of diabetes for more than a year, according to the findings.
Quite a bit of work remains before testing will start on people. If they can raise enough money — they estimate $5 million to $10 million — they can proceed to testing on larger animals, such as pigs, dogs or primates, a next step that would be planned in conjunction with the U.S. Food and Drug Administration.
They hope to start human trials in three years.
DeFronzo and Doiron said they expect skepticism but said much of it will be driven by how unconventional their work is. Doiron added that, although the technique is unconventional in the context of diabetes, using a virus to deliver a gene transfer is an established technique, having been approved dozens of times by the FDA to treat diseases.
"We can use the cells the body has naturally," Doiron said. "This will simply wake up the cells to produce insulin."
Type 1 and Type 2 diabetes
The work of Bruno Doiron and Ralph DeFronzo focuses on Type 1 diabetes, not Type 2.
Both diseases involve a problem with insulin, the substance that healthy bodies produce to take sugar from the bloodstream into the cells and power the body.
Type 2 is far more common. The main issue is that the cells reject insulin, causing sugar to build up in the bloodstream. The common treatment is a pill that makes the cells accept the insulin (and sugar it carries into the cell). But over time, people with Type 2 diabetes often lose the ability to produce insulin.
With Type 1 diabetes, people simply stop producing insulin. Their bodies kill off the cells in the pancreas that produce it.
Those with Type 1 diabetes must inject or ingest insulin. People with Type 2 often grow increasingly dependent on insulin injections, though Type 2 can sometimes be cured or controlled through diet and exercise.
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| posted on 4/25/2017 at 03:46 PM|
|Researchers have been trying to do Islet cell transplants since 1988, I knew one who was working on it back then, but his efforts were unsuccessful. |
The general public needs to understand that food can cause some diabetes. Overloading your body with sugar is very bad. Those of us (self included) that have genetically influenced insulin resistance have to be careful. Chromium (a mineral) can help people who are in pre-diabetes and those with insulin resistance because it increases sensitivity to insulin, so your body will produce less in response to food, thereby helping to preserve your natural insulin cells.
I also read recently that diet soda is really bad, the additivies have been linked to dementia and alzheimers, though you know the lobbyists will try to suppress that.
A good rule of thumb is, if God didn't make it, you don't need it, or need it in the form some company is pushing on you.
"Mankind is a single nation" "Allah did not make you a single people so he could try you in what he gave you, to him you will all return, he will inform you where you differed". Quran Chapter 2 Sura 213
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| posted on 4/27/2017 at 11:46 AM|
|Gina's right about sugar, but it's worse than that. When the body digests starches (some of the best foods, IMHO), it converts them into simple sugars. This takes longer, but still, they're pretty much the equivalent of timed-release sugar.|
Canis Major: The Original Skydog
"I can't say as ever I was lost, but I was bewildered once for three days."
World Class Peach
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| posted on 4/27/2017 at 02:16 PM|
SCIENCE 04/26/2017 02:22 pm ET
Study Shows Gut-Calming Effects Of Chili Peppers And Marijuana
By Steven Hoffer
A common link between chili peppers and marijuana could have implications for how we treat diabetes and colitis, as well as other conditions in the digestive tract, according to a new study from the University of Connecticut.
The study was published in the April 24 issue of the journal Proceedings of the National Academy of Sciences.
Researchers say chemicals found in the peppers and marijuana interact with the same receptor in our stomachs.
Scientists first focused on the chemical capsaicin, which is responsible for the hot sensation of eating a chili pepper. They fed capsaicin to mice, and “found the mice fed with the spice had less inflammation in their guts.”
Here’s a rundown of what happened next:
When they looked carefully at what was happening at a molecular level, the researchers saw that the capsaicin was binding to a receptor called TRPV1, which is found on specialized cells throughout the gastrointestinal tract. When capsaicin binds to it, TRPV1 causes cells to make anandamide. Anandamide is a compound chemically akin to the cannabinoids in marijuana. It was the anandamide that caused the immune system to calm down.
Knowing that the brain also has anandamide receptors, researchers began to “imagine ways the immune system and the brain might talk to each other” through the common language of the anandamide, explained Pramod Srivastava, professor of immunology and medicine at UConn School of Medicine.
Researchers found that a greater presence of anandamide led to a greater presence of macrophages, immune cells that curb inflammation.
The researchers actually managed to cure mice with Type 1 diabetes by feeding them chili peppers. When they skipped to feeding the mice anandamide directly, they observed a similar gut-calming result.
Researchers want to head to Colorado, where pot is legal, so they can further study the effects of ingesting marijuana on anandamide in the body.
“I’m hoping to work with the public health authority in Colorado to see if there has been an effect on the severity of colitis among regular users of edible weed,” Srivastava said in a press release.
The findings could have implications for various conditions found in the stomach, pancreas, intestines and colon.
Flies all green 'n buzzin' in his dungeon of despair
Who are all those people that he's locked away up there
Are they crazy?,
Are they sainted?
Are they zeros someone painted?,
It has never been explained since at first it was created
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| posted on 4/27/2017 at 03:01 PM|
|How about "chili pepper" & "marijuana" infused ice cream? |
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